Santiago Creek is a major watercourse in Orange County in the U.S. state of California. About 34 miles (55 km) long, it drains most of the northern Santa Ana Mountains and is a tributary to the Santa Ana River. It is one of the longest watercourses entirely within the county. The creek shares its name with Santiago Peak, at 5,687 ft (1,733 m) the highest point in Orange County, on whose slopes its headwaters rise.